Ontology highlight
ABSTRACT:
SUBMITTER: Tacconi EM
PROVIDER: S-EPMC6609913 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Tacconi Eliana Mc EM Badie Sophie S De Gregoriis Giuliana G Reisländer Timo T Lai Xianning X Porru Manuela M Folio Cecilia C Moore John J Kopp Arnaud A Baguña Torres Júlia J Sneddon Deborah D Green Marcus M Dedic Simon S Lee Jonathan W JW Batra Ankita Sati AS Rueda Oscar M OM Bruna Alejandra A Leonetti Carlo C Caldas Carlos C Cornelissen Bart B Brino Laurent L Ryan Anderson A Biroccio Annamaria A Tarsounas Madalena M
EMBO molecular medicine 20190524 7
Due to compromised homologous recombination (HR) repair, BRCA1- and BRCA2-mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression. To identify drugs that target specifically BRCA2-deficient cells, we screened a chemical library containing compounds in clinical use. The top hit was chlorambucil, a bifunctional alkylating agent used for the treatment of chronic lymphocytic leukaemia (CLL). We establish that chlorambucil is specifically toxic to BRCA1/2-defi ...[more]