Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6906494 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Wang Yifan Y Bernhardy Andrea J AJ Nacson Joseph J Krais John J JJ Tan Yin-Fei YF Nicolas Emmanuelle E Radke Marc R MR Handorf Elizabeth E Llop-Guevara Alba A Balmaña Judith J Swisher Elizabeth M EM Serra Violeta V Peri Suraj S Johnson Neil N
Nature communications 20191211 1
BRCA1 mutant carcinomas are sensitive to PARP inhibitor (PARPi) therapy; however, resistance arises. BRCA1 BRCT domain mutant proteins do not fold correctly and are subject to proteasomal degradation, resulting in PARPi sensitivity. In this study, we show that cell lines and patient-derived tumors, with highly disruptive BRCT domain mutations, have readily detectable BRCA1 protein expression, and are able to proliferate in the presence of PARPi. Peptide analyses reveal that chemo-resistant cance ...[more]