Ontology highlight
ABSTRACT:
SUBMITTER: Pydi SP
PROVIDER: S-EPMC6610117 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190703 1
β-Arrestins are major regulators of G protein-coupled receptor-mediated signaling processes. Their potential roles in regulating adipocyte function in vivo remain unexplored. Here we report the novel finding that mice lacking β-arrestin-2 (barr2) selectively in adipocytes show significantly reduced adiposity and striking metabolic improvements when consuming excess calories. We demonstrate that these beneficial metabolic effects are due to enhanced signaling through adipocyte β3-adrenergic recep ...[more]