Ontology highlight
ABSTRACT:
SUBMITTER: Garcia VJ
PROVIDER: S-EPMC6610155 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Garcia Veronica J VJ Rushton David J DJ Tom Colton M CM Allen Nicholas D ND Kemp Paul J PJ Svendsen Clive N CN Mattis Virginia B VB
Frontiers in neuroscience 20190628
In Huntington's disease (HD), while the ubiquitously expressed mutant Huntingtin (mtHTT) protein primarily compromises striatal and cortical neurons, glia also undergo disease-contributing alterations. Existing HD models using human induced pluripotent stem cells (iPSCs) have not extensively characterized the role of mtHTT in patient-derived astrocytes. Here physiologically mature astrocytes are generated from HD patient iPSCs. These human astrocytes exhibit hallmark HD phenotypes that occur in ...[more]