Ontology highlight
ABSTRACT:
SUBMITTER: Ragagnin AMG
PROVIDER: S-EPMC6610326 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ragagnin Audrey M G AMG Shadfar Sina S Vidal Marta M Jamali Md Shafi MS Atkin Julie D JD
Frontiers in neuroscience 20190627
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord. The neurodegenerative mechanisms leading to MN loss in ALS are not fully understood. Importantly, the reasons why MNs are specifically targeted in this disorder are unclear, when the proteins associated genetically or pathologically with ALS are expressed ubiquitously. Furthermore, MNs themselves are not affected equall ...[more]