Ontology highlight
ABSTRACT:
SUBMITTER: Xu M
PROVIDER: S-EPMC6610787 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Xu Miao M Yao Youyuan Y Chen Hui H Zhang Shanshan S Cao Su-Mei SM Zhang Zhe Z Luo Bing B Liu Zhiwei Z Li Zilin Z Xiang Tong T He Guiping G Feng Qi-Sheng QS Chen Li-Zhen LZ Guo Xiang X Jia Wei-Hua WH Chen Ming-Yuan MY Zhang Xiao X Xie Shang-Hang SH Peng Roujun R Chang Ellen T ET Pedergnana Vincent V Feng Lin L Bei Jin-Xin JX Xu Rui-Hua RH Zeng Mu-Sheng MS Ye Weimin W Adami Hans-Olov HO Lin Xihong X Zhai Weiwei W Zeng Yi-Xin YX Liu Jianjun J
Nature genetics 20190617 7
Epstein-Barr virus (EBV) infection is ubiquitous worldwide and is associated with multiple cancers, including nasopharyngeal carcinoma (NPC). The importance of EBV viral genomic variation in NPC development and its striking epidemic in southern China has been poorly explored. Through large-scale genome sequencing of 270 EBV isolates and two-stage association study of EBV isolates from China, we identify two non-synonymous EBV variants within BALF2 that are strongly associated with the risk of NP ...[more]