Ontology highlight
ABSTRACT:
SUBMITTER: Hoppstadter J
PROVIDER: S-EPMC6611420 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Hoppstädter Jessica J Ammit Alaina J AJ
Frontiers in immunology 20190626
Glucocorticoids (GCs) potently inhibit pro-inflammatory responses and are widely used for the treatment of inflammatory diseases, such as allergies, autoimmune disorders, and asthma. Dual-specificity phosphatase 1 (DUSP1), also known as mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), exerts its effects by dephosphorylation of MAPKs, i.e., extracellular-signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK). Endogenous DUSP1 expression is tightly regulated at multipl ...[more]