Ontology highlight
ABSTRACT:
SUBMITTER: Smallie T
PROVIDER: S-EPMC4472943 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Smallie Tim T Ross Ewan A EA Ammit Alaina J AJ Cunliffe Helen E HE Tang Tina T Rosner Dalya R DR Ridley Michael L ML Buckley Christopher D CD Saklatvala Jeremy J Dean Jonathan L JL Clark Andrew R AR
Journal of immunology (Baltimore, Md. : 1950) 20150527 1
Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wide variety of experimental inflammatory challenges. The principal mechanisms behind the overexpression of inflammatory mediators by Dusp1(-/-) cells are not known. In this study, we use a genetic approa ...[more]