Ethnic differences in progression of islet autoimmunity and type 1 diabetes in relatives at risk.

ABSTRACT:

Aims/hypothesis

We hypothesised that progression of islet autoimmunity and type 1 diabetes mellitus differs among races/ethnicities in at-risk individuals.

Methods

In this study, we analysed the data from the Type 1 Diabetes TrialNet Pathway to Prevention Study. We studied 4873 non-diabetic, autoantibody-positive relatives of individuals with type 1 diabetes followed prospectively (11% Hispanic, 80.9% non-Hispanic white [NHW], 2.9% non-Hispanic black [NHB] and 5.2% non-Hispanic other [NHO]). Primary outcomes were time from single autoantibody positivity confirmation to multiple autoantibody positivity, and time from multiple autoantibody positivity to type 1 diabetes mellitus diagnosis.

Results

Conversion from single to multiple autoantibody positivity was less common

SUBMITTER: Tosur M 

PROVIDER: S-EPMC6611550 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature