Dataset Information

Association of serum 25-hydroxyvitamin D concentrations with sleep phenotypes in a German community sample.

ABSTRACT:

Background

Sleep disorders and vitamin D deficiency are among the most common health problems. Few studies investigated the effect of vitamin D on objectively recorded sleep with sound methodological quality and reasonable temporal proximity.

Objective

To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) concentrations and objective sleep parameters assessed within close temporal proximity in a population-based sample. It is expected that higher serum 25(OH)D concentrations are associated with 1) better objective sleep outcomes (longer sleep duration, higher sleep efficiency, earlier mid-sleep time) and 2) more positive subjective sleep evaluations.

Methods

A subset of participants (n = 1045) from the LIFE-Adult-Study was analysed. Measurement of serum 25(OH)D vitamin was performed using an electrochemiluminescence immunoassay. Actigraphic assessments were performed using SenseWear Pro 3 devices. The following objective sleep parameters were calculated: total sleep duration, night sleep duration, night sleep efficiency, midsleep time and wake after sleep onset (WASO). Subjective sleep evaluations were assessed via questionnaire (sleep quality (PSQI), daytime sleepiness (ESS)). Data were analysed applying a multiple linear regression model with a stepwise approach.

Results

The regression models revealed significant associations of serum 25(OH)D concentration with night sleep duration and midsleep time. No association was found for total sleep duration and night sleep efficiency. Higher serum 25(OH)D concentration was further associated with shorter WASO in males but longer WASO in females. Moreover, serum 25(OH)D concentration did not show any significant association with subjective sleep quality and daytime sleepiness.

Conclusion

The results indicate that a higher concentration of serum 25(OH)D is associated with longer and earlier night sleep. Although the present study was able to demonstrate an association between serum 25(OH)D concentration and objective sleep parameters, no conclusion about underlying mechanisms or causal inferences can be drawn.

SUBMITTER: Dogan-Sander E

PROVIDER: S-EPMC6611612 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Association of serum 25-hydroxyvitamin D concentrations with sleep phenotypes in a German community sample.

Dogan-Sander Ezgi E Willenberg Anja A Batmaz İnci İ Enzenbach Cornelia C Wirkner Kerstin K Kohls Elisabeth E Mergl Roland R Thiery Joachim J Kratzsch Jürgen J Hegerl Ulrich U Sander Christian C

PloS one 20190705 7

<h4>Background</h4>Sleep disorders and vitamin D deficiency are among the most common health problems. Few studies investigated the effect of vitamin D on objectively recorded sleep with sound methodological quality and reasonable temporal proximity.<h4>Objective</h4>To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) concentrations and objective sleep parameters assessed within close temporal proximity in a population-based sample. It is expected that higher serum 25(OH) ...[more]

PMID: 31276483

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Dataset Information

Association of serum 25-hydroxyvitamin D concentrations with sleep phenotypes in a German community sample.

Background

Objective

Methods

Results

Conclusion

Publications

Association of serum 25-hydroxyvitamin D concentrations with sleep phenotypes in a German community sample.

Similar Datasets

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