ACE gene polymorphism and its association with serum erythropoietin and hemoglobin ?in Iraqi hemodialysis patients.

ABSTRACT:

Purpose

To evaluate the frequencies of angiotensin-converting enzyme gene ?polymorphism in ?Iraqi hemodialysis patients and to examine the association ?between this polymorphism and ?serum erythropoietin and hemoglobin levels.?.

Methods

In this study, 70 chronic renal failure Iraqi patients on ?maintenance ?hemodialysis (patient group) and 20 healthy subjects (control ?group) were genotyped for ?angiotensin-converting enzyme gene polymorphism. The distribution of genotype and allele ?frequencies of this polymorphism in ?these subjects were also evaluated.?.

Results

The distribution of angiotensin-converting enzyme genotypes between ?groups was ?similar, and the ID genotype was the most frequent, followed by DD and II ?genotypes (?50%?, ?37%?, and ?13%). The control group ?had a nonsignificant difference in serum ?erythropoietin levels among different angiotensin-converting enzyme genotypes, ?while patients with ID and DD genotypes displayed significant ?elevation in ?serum erythropoietin with time. No significant differences in hemoglobin ?levels ?were observed in patient and control groups. A significant positive correlation ?was ?observed between serum erythropoietin and hemoglobin in the control group ?with different ?angiotensin-converting enzyme genotypes, while a nonsignificant ?negative correlation was ?observed in the patient group throughout the study. ?.

Conclusions

Chronic kidney disease did not significantly alter angiotensin-converting enzyme ?genotypes, and angiotensin-converting enzyme gene ?polymorphism had a significant effect on ?serum erythropoietin levels and a non?significant effect on hemoglobin levels. ?.

SUBMITTER: Al-Radeef MY 

PROVIDER: S-EPMC6611710 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature