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Nocturnal Hemodialysis Improves Erythropoietin Responsiveness

ABSTRACT: Nocturnal home hemodialysis (NHD) [5 – 6 times a week, 6-8 hours per session] augments uremia clearance and is associated with an increase in hemoglobin level. We have used microarray to have a global image of the changes at the gene expression. Keywords: Treatment

ORGANISM(S): Homo sapiens

PROVIDER: GSE11227 | GEO | 2008/12/20

SECONDARY ACCESSION(S): PRJNA106839

REPOSITORIES: GEO

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Transcription profiling of human stable end-stage renal disease patients reveals nocturnal hemodialysis improves erythropoietin responsiveness

Project description:Nocturnal home hemodialysis (NHD) [5 Ã¢ÂÂ 6 times a week, 6-8 hours per session] augments uremia clearance and is associated with an increase in hemoglobin level. We have used microarray to have a global image of the changes at the gene expression. Experiment Overall Design: Sixteen stable end-stage renal disease patients (age: 47 ÃÂ± 2 years; 9M) [mean ÃÂ± SEM] were studied. Total RNA (TRNA) was isolated from whole blood before and after 3 months of established NHD. Gene expression before and after NHD was acquired through hybridizations on Human HG-U133_PLUS2 GeneChip and genes with differential gene expression were identified.

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