Ontology highlight
ABSTRACT:
SUBMITTER: Van Opdenbosch N
PROVIDER: S-EPMC6611727 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Van Opdenbosch Nina N Lamkanfi Mohamed M
Immunity 20190601 6
Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important advancements include the identification of additional inflammasome platforms and pathways that regulate activation of inflammatory caspases; the discovery of gasdermin D as the effector of pyroptosis and interleukin (IL)-1 and I ...[more]