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DNA nanostructures: A versatile lab-bench for interrogating biological reactions.

ABSTRACT: At its inception DNA nanotechnology was conceived as a tool for spatially arranging biological molecules in a programmable and deterministic way to improve their interrogation. To date, DNA nanotechnology has provided a versatile toolset of nanostructures and functional devices to augment traditional single molecule investigation approaches - including atomic force microscopy - by isolating, arranging and contextualising biological systems at the single molecule level. This review explores the state-of-the-art of DNA-based nanoscale tools employed to enhance and tune the interrogation of biological reactions, the study of spatially distributed pathways, the visualisation of enzyme interactions, the application and detection of forces to biological systems, and biosensing platforms.

SUBMITTER: Lee AJ

PROVIDER: S-EPMC6611922 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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DNA nanostructures: A versatile lab-bench for interrogating biological reactions.

Lee Andrew J AJ Wälti Christoph C

Computational and structural biotechnology journal 20190614

At its inception DNA nanotechnology was conceived as a tool for spatially arranging biological molecules in a programmable and deterministic way to improve their interrogation. To date, DNA nanotechnology has provided a versatile toolset of nanostructures and functional devices to augment traditional single molecule investigation approaches - including atomic force microscopy - by isolating, arranging and contextualising biological systems at the single molecule level. This review explores the s ...[more]

PMID: 31316727

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