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Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.

ABSTRACT: Atomoxetine is a nonstimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD). Cytochrome P450 (CYP)2D6 polymorphisms influence the metabolism of atomoxetine thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for atomoxetine based on CYP2D6 genotype (updates at www.cpicpgx.org).

SUBMITTER: Brown JT

PROVIDER: S-EPMC6612570 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.

Brown Jacob T JT Bishop Jeffrey R JR Sangkuhl Katrin K Nurmi Erika L EL Mueller Daniel J DJ Dinh Jean C JC Gaedigk Andrea A Klein Teri E TE Caudle Kelly E KE McCracken James T JT de Leon Jose J Leeder J Steven JS

Clinical pharmacology and therapeutics 20190413 1

Atomoxetine is a nonstimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD). Cytochrome P450 (CYP)2D6 polymorphisms influence the metabolism of atomoxetine thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for atomoxetine based on CYP2D6 genotype (updates at www.cpicpgx.org). ...[more]

PMID: 30801677

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