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Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.

ABSTRACT: The variant allele HLA-B*15:02 is strongly associated with greater risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with carbamazepine or oxcarbazepine. The variant allele HLA-A*31:01 is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS/TEN in patients treated with carbamazepine. We summarize evidence from the published literature supporting these associations and provide recommendations for carbamazepine and oxcarbazepine use based on HLA genotypes.

SUBMITTER: Phillips EJ

PROVIDER: S-EPMC5847474 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.

Phillips Elizabeth J EJ Sukasem Chonlaphat C Whirl-Carrillo Michelle M Müller Daniel J DJ Dunnenberger Henry M HM Chantratita Wasun W Goldspiel Barry B Chen Yuan-Tsong YT Carleton Bruce C BC George Alfred L AL Mushiroda Taisei T Klein Teri T Gammal Roseann S RS Pirmohamed Munir M

Clinical pharmacology and therapeutics 20180202 4

The variant allele HLA-B*15:02 is strongly associated with greater risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with carbamazepine or oxcarbazepine. The variant allele HLA-A*31:01 is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS/TEN in patients treated with carbamazepine. We summarize evidence from the published literature supporting these associations and provide recommen ...[more]

PMID: 29392710

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