Ontology highlight
ABSTRACT:
SUBMITTER: Adams JJ
PROVIDER: S-EPMC3253265 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Immunity 20111101 5
T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is essential to adaptive immunity, but it is unknown whether TCR signaling responses are influenced by the binding topology of the TCR-peptide-MHC complex. We developed yeast-displayed pMHC libraries that enabled us to identify new peptide sequences reactive with a single TCR. Structural analysis showed that four peptides bound to the TCR with distinct 3D and 2D affinities using entirely different binding chemist ...[more]