Ontology highlight
ABSTRACT:
SUBMITTER: Hemnes AR
PROVIDER: S-EPMC6613216 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Hemnes Anna R AR Rathinasabapathy Anandharajan A Austin Eric A EA Brittain Evan L EL Carrier Erica J EJ Chen Xinping X Fessel Joshua P JP Fike Candice D CD Fong Peter P Fortune Niki N Gerszten Robert E RE Johnson Jennifer A JA Kaplowitz Mark M Newman John H JH Piana Robert R Pugh Meredith E ME Rice Todd W TW Robbins Ivan M IM Wheeler Lisa L Yu Chang C Loyd James E JE West James J
The European respiratory journal 20180621 6
Pulmonary arterial hypertension (PAH) is a deadly disease with no cure. Alternate conversion of angiotensin II (AngII) to angiotensin-(1-7) (Ang-(1-7)) by angiotensin-converting enzyme 2 (ACE2) resulting in Mas receptor (Mas1) activation improves rodent models of PAH. Effects of recombinant human (rh) ACE2 in human PAH are unknown. Our objective was to determine the effects of rhACE2 in PAH.We defined the molecular effects of Mas1 activation using porcine pulmonary arteries, measured AngII/Ang-( ...[more]