Ontology highlight
ABSTRACT:
SUBMITTER: Brickner DG
PROVIDER: S-EPMC6613381 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Developmental cell 20190601 6
Loss of nuclear pore complex (NPC) proteins, transcription factors (TFs), histone modification enzymes, Mediator, and factors involved in mRNA export disrupts the physical interaction of chromosomal sites with NPCs. Conditional inactivation and ectopic tethering experiments support a direct role for the TFs Gcn4 and Nup2 in mediating interaction with the NPC but suggest an indirect role for factors involved in mRNA export or transcription. A conserved "positioning domain" within Gcn4 controls in ...[more]