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The relationship between prenatal psychological stress and placental abruption in Japan, The Japan Environment and Children's Study (JECS).

ABSTRACT: BACKGROUND:Prenatal psychological stress may increase the risk of placental abruption (PA). This study aimed to clarify the effects of psychological distress during pregnancy and exposure to stressful life events in the year before or during pregnancy on the occurrence of PA in Japanese women. METHODS:Using a nationwide prospective birth cohort study, we obtained data from 103,099 women between January 2011 and March 2014. Information on exposure to 14 stressful life events and psychological distress (Kessler 6 scale) was collected using a self-administered questionnaire during pregnancy. Clinical diagnoses of PA were obtained from medical records. A total of 80,799 women with singleton births were analyzed using logistic regression models that adjusted for possible confounders. RESULTS:PA was diagnosed in 335 (0.4%) women. There was no significant difference in the Kessler 6 score during pregnancy between the PA group and non-PA group. Exposure to the death of a child in the year before or during pregnancy was significantly associated with PA in multigravid women (adjusted odds ratio [aOR] 3.57; 95% confidence interval [CI] 1.50-8.34). A spouse's loss of employment was significantly associated with PA in parous women (aOR 3.25; 95% CI 1.40-7.56). CONCLUSIONS:This study identified the possible effects of exposure to the death of a child on PA occurrence that adjusted for important confounding factors.

SUBMITTER: Kawanishi Y

PROVIDER: S-EPMC6613679 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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The relationship between prenatal psychological stress and placental abruption in Japan, The Japan Environment and Children's Study (JECS).

Kawanishi Yasuyuki Y Yoshioka Eiji E Saijo Yasuaki Y Itoh Toshihiro T Miyamoto Toshinobu T Sengoku Kazuo K Ito Yoshiya Y Ito Sachiko S Miyashita Chihiro C Araki Atsuko A Endo Toshiaki T Cho Kazutoshi K Minakami Hisanori H Kishi Reiko R

PloS one 20190708 7

<h4>Background</h4>Prenatal psychological stress may increase the risk of placental abruption (PA). This study aimed to clarify the effects of psychological distress during pregnancy and exposure to stressful life events in the year before or during pregnancy on the occurrence of PA in Japanese women.<h4>Methods</h4>Using a nationwide prospective birth cohort study, we obtained data from 103,099 women between January 2011 and March 2014. Information on exposure to 14 stressful life events and ps ...[more]

PMID: 31283785

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Project description:BackgroundTo our knowledge, the association of maternal exposure to metallic elements with weight trajectory pattern from the neonatal period has not been investigated.ObjectivesThe goals of this study were to identify infant growth trajectories in weight in the first 3 y of life and to determine the associations of maternal blood levels of lead, cadmium, mercury, selenium, and manganese with growth trajectory.MethodsThis longitudinal study, part of the Japan Environment and Children Study, enrolled 103,099 pregnant women at 15 Regional Centres across Japan between 2011 and 2014. Lead, cadmium, mercury, selenium, and manganese levels were measured in blood samples collected in the second (14-27 wk gestational age) or third trimester (≥28wk). Growth trajectory of 99,014 children was followed until age 3 y. Raw weight values were transformed to age- and sex-specific weight standard deviation (SD) scores, and latent-class group-based trajectory models were estimated to determine weight trajectories. Associations between maternal metallic element levels and weight trajectory were examined using multinomial logistic regression models after confounder adjustment.ResultsWe identified 5 trajectory patterns based on weight SD score: 4.74% of infants were classified in Group I, very small to small; 31.26% in Group II, moderately small; 21.91% in Group III, moderately small to moderately large; 28.06% in Group IV, moderately large to normal; and 14.03% in Group V, moderately large to large. On multinomial logistic regression, higher maternal lead and selenium levels tended to be associated with increased odds ratios (ORs) of poor weight SD score trajectories (Groups I and II), in comparison with Group III. Higher levels of mercury were associated with decreased ORs, whereas higher levels of manganese were associated with increased ORs of "moderately large" trajectories (Groups IV and V).DiscussionMaternal lead, mercury, selenium, and manganese blood levels affect infant growth trajectory pattern in the first 3 y of life. https://doi.org/10.1289/EHP10321.

Dataset Information

The relationship between prenatal psychological stress and placental abruption in Japan, The Japan Environment and Children's Study (JECS).

Publications

The relationship between prenatal psychological stress and placental abruption in Japan, The Japan Environment and Children's Study (JECS).

Similar Datasets

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