Dataset Information

Associations of prenatal exposure to impaired glucose tolerance with eating in the absence of hunger in early adolescence.

ABSTRACT: OBJECTIVE:Exposure to impaired gestational glucose tolerance has been shown to have sex-specific associations with offspring obesity risk, perhaps by affecting the development of appetite regulation. We examined the extent to which prenatal exposure to impaired glucose tolerance was associated with eating in the absence of hunger (EAH) in early adolescent offspring, and in turn, whether EAH was cross-sectionally associated with body composition. METHODS:We included data from 1097 adolescents participating in Project Viva, a pre-birth longitudinal cohort. We obtained the results of two-stage prenatal glycemic screening (50?g glucose challenge test, followed if abnormal by 100?g oral glucose tolerance test) at 26-28 weeks of gestation, and categorized mothers as having normal glucose tolerance, isolated hyperglycemia (IH, n?=?92, 8.4%), impaired glucose tolerance (IGT, n?=?36, 3.3%), or gestational diabetes mellitus (GDM, n?=?52, 4.7%). At a median age of 13 years, offspring reported on two modified items of the Eating in the Absence of Hunger in Children and Adolescents questionnaire, we measured height and weight, and performed dual X-ray absorptiometry scans to assess fat and fat-free mass. We used multivariable linear regression analyses adjusted for sociodemographic and prenatal covariates, including maternal pre-pregnancy BMI. RESULTS:On a ten-point scale, the mean (SD) EAH score was 4.4 points (SD?=?1.5) in boys and 4.4 (SD?=?1.4) in girls. In girls, prenatal exposure to both IH and IGT was associated with more EAH compared with normal glucose tolerance (e.g., for IH: 0.56 points, 95% CI: 0.17, 0.96), whereas in boys, prenatal exposure to IGT was associated with less EAH (-0.81 points, 95% CI: -1.41, -0.21). We did not observe an association between exposure to GDM and EAH, nor did we observe associations between EAH and body composition in early adolescence. CONCLUSIONS:These findings suggest sex-specific associations of exposure to impaired gestational glucose tolerance with offspring EAH in early adolescence.

SUBMITTER: Derks IPM

PROVIDER: S-EPMC6614016 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Associations of prenatal exposure to impaired glucose tolerance with eating in the absence of hunger in early adolescence.

Derks Ivonne P M IPM Hivert Marie-France MF Rifas-Shiman Sheryl L SL Gingras Véronique V Young Jessica G JG Jansen Pauline W PW Oken Emily E

International journal of obesity (2005) 20190108 10

<h4>Objective</h4>Exposure to impaired gestational glucose tolerance has been shown to have sex-specific associations with offspring obesity risk, perhaps by affecting the development of appetite regulation. We examined the extent to which prenatal exposure to impaired glucose tolerance was associated with eating in the absence of hunger (EAH) in early adolescent offspring, and in turn, whether EAH was cross-sectionally associated with body composition.<h4>Methods</h4>We included data from 1097 ...[more]

PMID: 30622313

Similar Datasets

Project description:BackgroundScant research has examined whether laboratory assessments of eating in the absence of hunger (EAH) relates to long-term diet quality.ObjectiveThis study investigates the association of EAH with diet quality during pregnancy.DesignPregnancy diet quality was assessed using 24-hour diet recalls collected in each pregnancy trimester. EAH was assessed in a counterbalanced, crossover laboratory feeding substudy in which participants completed two free access eating occasions following a standardized meal during their second pregnancy trimester.Participants/settingData were collected from March 2015 to December 2016 from a subsample of participants (n = 46) enrolled at ≤12 weeks' gestation in an observational, prospective cohort study (the Pregnancy Eating Attributes Study) in North Carolina.InterventionParticipants were presented with highly processed (HP) and minimally processed (MP) foods in two separate assessments.Main outcome measuresScores for total Healthy Eating Index-2015 (HEI-2015) and adherence to adequacy and moderation components were calculated from the diet recalls. Higher scores reflect better diet quality.Statistical analyses performedLinear regressions estimated associations of pregnancy diet quality with EAH (energy, EAH-kcal; and percent offered, EAH-%) in each condition for all foods, and separately for sweet and savory foods.ResultsLower pregnancy diet quality (all indicators) was associated with greater EAH (EAH-kcal and EAH-%) of all foods and sweet foods in the HP condition. Each 100-kcal increase in EAH of HP foods was associated with a 2- to 3-point decrease (standard error = 0.7 to 0.8) in HEI-2015 (P < 0.01); each 10% increase in EAH of HP foods was associated with a 5- to 7-point decrease (standard error = 2.0) in HEI-2015 (P < 0.01). Greater EAH (energy and percent offered) of savory food intake in the HP condition was associated with a lower HEI-2015 adequacy component score, but was not associated with the HEI-2015 or HEI-2015 moderation component scores. EAH in the MP condition was not associated with pregnancy diet quality.ConclusionsGreater EAH of HP, especially sweet, foods was related to worse pregnancy diet quality. Consuming HP sweets after meal termination may reflect a tendency for eating beyond satiation and may be a useful intervention target for improving maternal diet quality.

Dataset Information

Associations of prenatal exposure to impaired glucose tolerance with eating in the absence of hunger in early adolescence.

Publications

Associations of prenatal exposure to impaired glucose tolerance with eating in the absence of hunger in early adolescence.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets