Ontology highlight
ABSTRACT:
SUBMITTER: Cimdins K
PROVIDER: S-EPMC6614131 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Cimdins Kathryn K Waugh Hayley S HS Chrysostomou Vicki V Lopez Sanchez M Isabel G MIG Johannsen Vanessa A VA Cook Mark J MJ Crowston Jonathan G JG Hill Andrew F AF Duce James A JA Bush Ashley I AI Trounce Ian A IA
Molecular neurobiology 20190105 8
Mitochondrial complex I dysfunction is the most common respiratory chain defect in human disorders and a hotspot for neurodegenerative diseases. Amyloid precursor protein (APP) and its non-amyloidogenic processing products, in particular soluble APP α (sAPPα), have been shown to provide neuroprotection in models of neuronal injury; however, APP-mediated protection from acute mitochondrial injury has not been previously reported. Here, we use the plant-derived pesticide rotenone, a potent complex ...[more]