Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC6614449 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Huang Yunjie Y Arora Kavisha K Mun Kyu Shik KS Yang Fanmuyi F Moon ChangSuk C Yarlagadda Sunitha S Jegga Anil A Weaver Timothy T Naren Anjaparavanda P AP
Scientific reports 20190708 1
The molecular mechanism of Endoplasmic Reticulum-associated degradation (ERAD) of Cystic fibrosis transmembrane-conductance regulator (CFTR) is largely unknown. Particularly, it is unknown what ER luminal factor(s) are involved in ERAD. Herein, we used ProtoArray to identify an ER luminal co-chaperone, DNAJB9, which can directly interact with CFTR. For both WT- and ΔF508 (deletion of phenylalanine at position 508, the most common CF-causing mutant)-CFTR, knockdown of DNAJB9 by siRNA increased th ...[more]