Ontology highlight
ABSTRACT:
SUBMITTER: Zyner KG
PROVIDER: S-EPMC6615864 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
eLife 20190709
G-quadruplexes (G4) are alternative nucleic acid structures involved in transcription, translation and replication. Aberrant G4 formation and stabilisation is linked to genome instability and cancer. G4 ligand treatment disrupts key biological processes leading to cell death. To discover genes and pathways involved with G4s and gain mechanistic insights into G4 biology, we present the first unbiased genome-wide study to systematically identify human genes that promote cell death when silenced by ...[more]