Ontology highlight
ABSTRACT:
SUBMITTER: van den Berg FT
PROVIDER: S-EPMC6616373 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
van den Berg Fiona T FT Makoah Nigel A NA Ali Stuart A SA Scott Tristan A TA Mapengo Rutendo E RE Mutsvunguma Lorraine Z LZ Mkhize Nonhlanhla N NN Lambson Bronwen E BE Kgagudi Prudence D PD Crowther Carol C Abdool Karim Salim S SS Balazs Alejandro B AB Weinberg Marc S MS Ely Abdullah A Arbuthnot Patrick B PB Morris Lynn L
Molecular therapy. Methods & clinical development 20190612
HIV-1 infection continues to be a global health challenge and a vaccine is urgently needed. Broadly neutralizing antibodies (bNAbs) are considered essential as they inhibit multiple HIV-1 strains, but they are difficult to elicit by conventional immunization. In contrast, non-neutralizing antibodies that correlated with reduced risk of infection in the RV144 HIV vaccine trial are relatively easy to induce, but responses are not durable. To overcome these obstacles, adeno-associated virus (AAV) v ...[more]