Ontology highlight
ABSTRACT:
SUBMITTER: Voss JE
PROVIDER: S-EPMC5640805 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Voss James E JE Andrabi Raiees R McCoy Laura E LE de Val Natalia N Fuller Roberta P RP Messmer Terrence T Su Ching-Yao CY Sok Devin D Khan Salar N SN Garces Fernando F Pritchard Laura K LK Wyatt Richard T RT Ward Andrew B AB Crispin Max M Wilson Ian A IA Burton Dennis R DR
Cell reports 20171001 1
Recent efforts toward HIV vaccine development include the design of immunogens that can engage B cell receptors with the potential to affinity mature into broadly neutralizing antibodies (bnAbs). V2-apex bnAbs, which bind a protein-glycan region on HIV envelope glycoprotein (Env) trimer, are among the most broad and potent described. We show here that a rare "glycan hole" at the V2 apex is enriched in HIV isolates neutralized by inferred precursors of prototype V2-apex bnAbs. To investigate whet ...[more]