Ontology highlight
ABSTRACT:
SUBMITTER: Smith GA
PROVIDER: S-EPMC6616599 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Smith Gaynor A GA Lin Tzu-Huai TH Sheehan Amy E AE Van der Goes van Naters Wynand W Neukomm Lukas J LJ Graves Hillary K HK Bis-Brewer Dana M DM Züchner Stephan S Freeman Marc R MR
Neuron 20190514 1
Mitochondria are essential in long axons to provide metabolic support and sustain neuron integrity. A healthy mitochondrial pool is maintained by biogenesis, transport, mitophagy, fission, and fusion, but how these events are regulated in axons is not well defined. Here, we show that the Drosophila glutathione S-transferase (GST) Gfzf prevents mitochondrial hyperfusion in axons. Gfzf loss altered redox balance between glutathione (GSH) and oxidized glutathione (GSSG) and initiated mitochondrial ...[more]