Ontology highlight
ABSTRACT:
SUBMITTER: Dancy BM
PROVIDER: S-EPMC5178136 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Dancy Beverley M BM Brockway Nicole N Ramadasan-Nair Renjini R Yang Yoing Y Sedensky Margaret M MM Morgan Philip G PG
Mechanisms of ageing and development 20151215
To understand primary mitochondrial disease, we utilized a complex I-deficient Caenorhabditis elegans mutant, gas-1. These animals strongly upregulate the expression of gst-14 (encoding a glutathione S-transferase). Knockdown of gst-14 dramatically extends the lifespan of gas-1 and increases hydroxynonenal (HNE) modified mitochondrial proteins without improving complex I function. We observed no change in reactive oxygen species levels as measured by Mitosox staining, consistent with a potential ...[more]