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Identification of hepatitis B virus genotype I in Thailand.

ABSTRACT: The rare hepatitis B virus genotype I (HBV-I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV-I specimen from Thailand, with detectable HBsAg despite a 10-amino-acid truncation. This HBV-I genome has a similar recombinant pattern to reference strains, including a C region that branches basal to references, suggesting a premodern era recombination event gave rise to HBV-I. With an average sequence divergence from other genotypes ranging from 7.66% (standard deviation [SD], 0.42%; C) to 14.27% (SD, 0.31%; H), this new genome supports the HBV-I classification as a unique genotype.

SUBMITTER: Holzmayer V

PROVIDER: S-EPMC6618046 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Identification of hepatitis B virus genotype I in Thailand.

Holzmayer Vera V Hance Robert R Defechereux Patricia P Grant Robert R Kuhns Mary C MC Cloherty Gavin G Rodgers Mary A MA

Journal of medical virology 20181108 4

The rare hepatitis B virus genotype I (HBV-I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV-I specimen from Thailand, with detectable HBsAg despite a 10-amino-acid truncation. This HBV-I genome has a similar recombinant pattern to reference strains, including a C region that branches basal to references, suggesting a premodern era recombination event gave rise to HBV-I. With an average ...[more]

PMID: 30351478

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