Unknown

Dataset Information

0

Identification of hepatitis B virus genotype A/E recombinants in Ghana.


ABSTRACT: Hepatitis B virus (HBV) exhibits a high degree of heterogeneity with at least 10 genotypes (A-J) identified to date. Intergenotypic recombination is relatively common. Previously, we investigated HBV drug resistance in HIV/HBV co-infected individuals in Ghana. After identifying multiple circulating genotypes and a novel D/E recombinant, we sought to determine if additional individuals were also infected with recombinant HBV. Partial genome sequences from three individuals were initially identified as genotype A4. Full-length HBV genomes were obtained using rolling circle amplification followed by PCR and shown to cluster with known A/E recombinant viruses. Similar recombination breakpoints were observed in these three individuals suggesting local spread of this novel recombinant HBV in Ghana.

SUBMITTER: Boyce CL 

PROVIDER: S-EPMC6750976 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications


Hepatitis B virus (HBV) exhibits a high degree of heterogeneity with at least 10 genotypes (A-J) identified to date. Intergenotypic recombination is relatively common. Previously, we investigated HBV drug resistance in HIV/HBV co-infected individuals in Ghana. After identifying multiple circulating genotypes and a novel D/E recombinant, we sought to determine if additional individuals were also infected with recombinant HBV. Partial genome sequences from three individuals were initially identifi  ...[more]

Similar Datasets

| S-EPMC5710801 | biostudies-literature
| S-EPMC10281089 | biostudies-literature
| S-EPMC5412322 | biostudies-literature
| S-EPMC5444172 | biostudies-literature
| S-EPMC3404033 | biostudies-literature
| S-EPMC3067958 | biostudies-literature
| S-EPMC6618046 | biostudies-literature
| S-EPMC7993477 | biostudies-literature
| PRJDB10091 | ENA
| PRJNA339809 | ENA