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Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex.


ABSTRACT: Four-way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA-damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5'-d(CGTACG)-3' specifically into a 4WJ-like motif. In the crystal structure of the 1-CGTACG adduct, the distorted-square-planar platinum complex binds to the core of the 4WJ-like motif through ?-? stacking and hydrogen bonding, without forming any platinum-nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure.

SUBMITTER: van Rixel VHS 

PROVIDER: S-EPMC6618160 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex.

van Rixel Vincent H S VHS   Busemann Anja A   Wissingh Mathijs F MF   Hopkins Samantha L SL   Siewert Bianka B   van de Griend Corjan C   Siegler Maxime A MA   Marzo Tiziano T   Papi Francesco F   Ferraroni Marta M   Gratteri Paola P   Bazzicalupi Carla C   Messori Luigi L   Bonnet Sylvestre S  

Angewandte Chemie (International ed. in English) 20190528 28


Four-way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA-damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5'-d(CGTACG)-3' specifically into a 4WJ-like motif. In the crystal structure of the 1-CGTACG adduct, the distorted-square-planar platinum complex binds to the core of the 4WJ-like motif through π-π stacking and hy  ...[more]

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