Ontology highlight
ABSTRACT:
SUBMITTER: van Rixel VHS
PROVIDER: S-EPMC6618160 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20190528 28
Four-way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA-damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5'-d(CGTACG)-3' specifically into a 4WJ-like motif. In the crystal structure of the 1-CGTACG adduct, the distorted-square-planar platinum complex binds to the core of the 4WJ-like motif through π-π stacking and hy ...[more]