Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC6618663 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Kumar Sandeep S Mohapatra Alok Nath AN Sharma Hanuman Prasad HP Singh Utkarsha A UA Kambi Niranjan Ashok NA Velpandian Thirumurthy T Rajan Raghav R Iyengar Soumya S
Frontiers in neuroscience 20190703
Although the interplay between endogenous opioids and dopamine (DA) in the basal ganglia (BG) is known to underlie diverse motor functions, few studies exist on their role in modulating speech and vocalization. Vocal impairment is a common symptom of Parkinson's disease (PD), wherein DA depletion affects striosomes rich in μ-opioid receptors (μ-ORs). Symptoms of opioid addiction also include deficiencies in verbal functions and speech. To understand the interplay between the opioid system and BG ...[more]