Ontology highlight
ABSTRACT:
SUBMITTER: Vukovic J
PROVIDER: S-EPMC6619068 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Vukovic Jana J Borlikova Gilyana G GG Ruitenberg Marc J MJ Robinson Gregory J GJ Sullivan Robert K P RK Walker Tara L TL Bartlett Perry F PF
The Journal of neuroscience : the official journal of the Society for Neuroscience 20130401 15
It is now widely accepted that hippocampal neurogenesis underpins critical cognitive functions, such as learning and memory. To assess the behavioral importance of adult-born neurons, we developed a novel knock-in mouse model that allowed us to specifically and reversibly ablate hippocampal neurons at an immature stage. In these mice, the diphtheria toxin receptor (DTR) is expressed under control of the doublecortin (DCX) promoter, which allows for specific ablation of immature DCX-expressing ne ...[more]