Ontology highlight
ABSTRACT:
SUBMITTER: Lahdenpohja S
PROVIDER: S-EPMC6619244 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Lahdenpohja Salla S Keller Thomas T Rajander Johan J Kirjavainen Anna K AK
Journal of labelled compounds & radiopharmaceuticals 20190501 6
[<sup>18</sup> F]NS12137 (exo-3-[(6-[<sup>18</sup> F]fluoro-2-pyridyl)oxy]8-azabicyclo[3.2.1]octane) is a highly selective norepinephrine transporter (NET) tracer. NETs are responsible for the reuptake of norepinephrine and dopamine and are linked to several neurodegenerative and neuropsychiatric disorders. The aim of this study was to develop a copper-mediated <sup>18</sup> F-fluorination method for the production of [<sup>18</sup> F]NS12137 with straightforward synthesis conditions and high ra ...[more]