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A one-pot radiosynthesis of [18 F]PARPi.


ABSTRACT: In this paper, we disclose a new strategy for the radiosynthesis of [18 F]PARPi from the corresponding, boc-protected, nitro-precursor. Using a two-step procedure, [18 F]PARPi could be isolated in radiochemical yields up to 9.6%. The reaction proceeds via an efficient one-pot, two-step process, allowing for simplification over previous methods that require complex multi-step, multi-pot strategies to be implemented.

SUBMITTER: Wilson TC 

PROVIDER: S-EPMC7551923 | biostudies-literature |

REPOSITORIES: biostudies-literature

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