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Cholecalciferol supplementation does not influence ?-cell function and insulin action in obese adolescents: a prospective double-blind randomized trial.

ABSTRACT: BACKGROUND:There is increasing interest in the extraskeletal effects of vitamin D, particularly in the obese state with regard to the development of insulin resistance and diabetes. OBJECTIVE:The objective of the study was to determine the effect of 2 doses of cholecalciferol (vitamin D3) supplementation on insulin action (Si) and pancreatic ?-cell function in obese adolescents. METHODS:We performed a 12-wk double-blind, randomized comparison of the effect of vitamin D3 supplementation on Si and ?-cell function in obese Caucasian adolescents (body mass index > 95(th) percentile). The subjects were randomly assigned to receive either 400 IU/d (n = 25) or 2000 IU/d (n = 26) of vitamin D3. Each subject underwent a 7-sample 75 g oral glucose tolerance test, with glucose, insulin, and C-peptide measurements, to calculate Si and ?-cell function as assessed by the disposition index (DI), with use of the oral minimal model before and after supplementation. A total of 51 subjects aged 15.0 ± 1.9 y were enrolled. Included for analysis at follow-up were a total of 46 subjects (20 male and 26 female adolescents), 23 in each group. RESULTS:Initial serum 25-hydroxyvitamin D [25(OH)D] was 24.0 ± 8.1 ?g/L. There was no correlation between 25(OH)D concentrations and Si or DI. There was a modest but significant increase in 25(OH)D concentration in the 2000 IU/d group (3.1 ± 6.5 ?g/L, P = 0.04) but not in the 400 IU/d group (P = 0.39). There was no change in Si or DI following vitamin D3 supplementation in either of the treatment groups (all P > 0.10). CONCLUSIONS:The current study shows no effect from vitamin D3 supplementation, irrespective of its dose, on ?-cell function or insulin action in obese nondiabetic adolescents with relatively good vitamin D status. Whether obese adolescents with vitamin D deficiency and impaired glucose metabolism would respond differently to vitamin D3 supplementation remains unclear and warrants further studies. This trial was registered at clinicaltrials.gov as NCT00858247.

SUBMITTER: Javed A

PROVIDER: S-EPMC6619681 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Cholecalciferol supplementation does not influence β-cell function and insulin action in obese adolescents: a prospective double-blind randomized trial.

Javed Asma A Vella Adrian A Balagopal P Babu PB Fischer Philip R PR Weaver Amy L AL Piccinini Francesca F Dalla Man Chiara C Cobelli Claudio C Giesler Paula D PD Laugen Jeanette M JM Kumar Seema S

The Journal of nutrition 20141217 2

<h4>Background</h4>There is increasing interest in the extraskeletal effects of vitamin D, particularly in the obese state with regard to the development of insulin resistance and diabetes.<h4>Objective</h4>The objective of the study was to determine the effect of 2 doses of cholecalciferol (vitamin D3) supplementation on insulin action (Si) and pancreatic β-cell function in obese adolescents.<h4>Methods</h4>We performed a 12-wk double-blind, randomized comparison of the effect of vitamin D3 sup ...[more]

PMID: 25644349

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Cholecalciferol supplementation does not influence ?-cell function and insulin action in obese adolescents: a prospective double-blind randomized trial.

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Cholecalciferol supplementation does not influence β-cell function and insulin action in obese adolescents: a prospective double-blind randomized trial.

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