Ontology highlight
ABSTRACT:
SUBMITTER: Jamshad M
PROVIDER: S-EPMC6620043 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Jamshad Mohammed M Knowles Timothy J TJ White Scott A SA Ward Douglas G DG Mohammed Fiyaz F Rahman Kazi Fahmida KF Wynne Max M Hughes Gareth W GW Kramer Günter G Bukau Bernd B Huber Damon D
eLife 20190627
In bacteria, the translocation of proteins across the cytoplasmic membrane by the Sec machinery requires the ATPase SecA. SecA binds ribosomes and recognises nascent substrate proteins, but the molecular mechanism of nascent substrate recognition is unknown. We investigated the role of the C-terminal tail (CTT) of SecA in nascent polypeptide recognition. The CTT consists of a flexible linker (FLD) and a small metal-binding domain (MBD). Phylogenetic analysis and ribosome binding experiments indi ...[more]