Ontology highlight
ABSTRACT:
SUBMITTER: Smith N
PROVIDER: S-EPMC6620093 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Science advances 20190710 7
Type I interferons are highly potent cytokines essential for self-protection against tumors and infections. Deregulations of type I interferon signaling are associated with multiple diseases that require novel therapeutic options. Here, we identified the small molecule, IT1t, a previously described CXCR4 ligand, as a highly potent inhibitor of Toll-like receptor 7 (TLR7)-mediated inflammation. IT1t inhibits chemical (R848) and natural (HIV) TLR7-mediated inflammation in purified human plasmacyto ...[more]