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Inhibition of fibronectin polymerization alleviates kidney injury due to ischemia-reperfusion.

ABSTRACT: Fibrosis is a common feature of chronic kidney disease; however, no clinical therapies effectively target the progression of fibrosis. Inhibition of fibronectin polymerization with the small peptide pUR4 attenuates fibrosis in the liver and heart. Here, we show that pUR4 decreases renal fibrosis and tissue remodeling using a clinically relevant model of kidney injury, unilateral ischemia-reperfusion. This work highlights the benefits of inhibiting matrix polymerization, alone or in conjunction with cell-based therapies, as a novel approach to diminish the maladaptive responses to ischemic kidney injury that lead to chronic renal failure.

SUBMITTER: Bowers SLK

PROVIDER: S-EPMC6620592 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Inhibition of fibronectin polymerization alleviates kidney injury due to ischemia-reperfusion.

Bowers Stephanie L K SLK Davis-Rodriguez Stephanie S Thomas Zachary M ZM Rudomanova Valeria V Bacon W Clark WC Beiersdorfer Alex A Ma Qing Q Devarajan Prasad P Blaxall Burns C BC

American journal of physiology. Renal physiology 20190424 6

Fibrosis is a common feature of chronic kidney disease; however, no clinical therapies effectively target the progression of fibrosis. Inhibition of fibronectin polymerization with the small peptide pUR4 attenuates fibrosis in the liver and heart. Here, we show that pUR4 decreases renal fibrosis and tissue remodeling using a clinically relevant model of kidney injury, unilateral ischemia-reperfusion. This work highlights the benefits of inhibiting matrix polymerization, alone or in conjunction w ...[more]

PMID: 31017009

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