Ontology highlight
ABSTRACT:
SUBMITTER: Jung HY
PROVIDER: S-EPMC7554761 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Jung Hee-Yeon HY Oh Se-Hyun SH Ahn Ji-Sun JS Oh Eun-Joo EJ Kim You-Jin YJ Kim Chan-Duck CD Park Sun-Hee SH Kim Yong-Lim YL Cho Jang-Hee JH
International journal of molecular sciences 20200921 18
The protective effects of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) 1 inhibition against kidney ischemia-reperfusion injury (IRI) remain uncertain. The bilateral kidney pedicles of C57BL/6 mice were clamped for 30 min to induce IRI. Madin-Darby Canine Kidney (MDCK) cells were incubated with H<sub>2</sub>O<sub>2</sub> (1.4 mM) for 1 h to induce oxidative stress. ML171, a selective NOX1 inhibitor, and siRNA against NOX1 were treated to inhibit NOX1. NOX expression, oxidativ ...[more]