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Integration of a photocleavable element into DNA nanoswitches.

ABSTRACT: Reconfigurable DNA nanostructures can be designed to respond to external stimuli such as nucleic acids, pH, small molecules and enzymes. In this study, we incorporated photocleavable linkers in DNA strands that trigger a conformational change in binary DNA nanoswitches. We demonstrate control of the output using UV light, with potential applications in biosensing and molecular computation.

SUBMITTER: Chandrasekaran AR

PROVIDER: S-EPMC6620779 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Integration of a photocleavable element into DNA nanoswitches.

Chandrasekaran Arun Richard AR Abraham Punnoose Jibin J Valsangkar Vibhav V Sheng Jia J Halvorsen Ken K

Chemical communications (Cambridge, England) 20190522 46

Reconfigurable DNA nanostructures can be designed to respond to external stimuli such as nucleic acids, pH, small molecules and enzymes. In this study, we incorporated photocleavable linkers in DNA strands that trigger a conformational change in binary DNA nanoswitches. We demonstrate control of the output using UV light, with potential applications in biosensing and molecular computation. ...[more]

PMID: 31116197

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