Unknown

Dataset Information

0

Influence of DNMT3A R882 mutations on AML prognosis determined by the allele ratio in Chinese patients.


ABSTRACT:

Background

The influence of DNMT3A R882 mutations on adult acute myeloid leukemia (AML) prognosis is still controversial presently. The influence of R882 allele ratio on drug response and prognosis of AML is unknown yet. Besides, it is obscure whether anthracyclines are involved in chemoresistance resulted from R882 mutations.

Methods

DNMT3A R882 mutations in 870 adult AML patients receiving standard induction therapy were detected by pyrosequencing. Associations of the mutants with responses to induction therapy and disease prognosis were analyzed.

Results

DNMT3A R882 mutations were detected in 74 (8.51%) patients and allele ratio of the mutations ranged from 6 to 50% in the cohort. After the first and second courses of induction therapy including aclarubicin, complete remission rates were significantly lower in carriers of the DNMT3A R882 mutants as compared with R882 wildtype patients (P = 0.022 and P = 0.038, respectively). Compared with R882 wild-type patients, those with the R882 mutations showed significantly shorter overall survival (OS) and disease-free survival (DFS) (P = 1.92 × 10-4 and P = 0.004, respectively). Patients with higher allele ratio of R882 mutations showed a significantly shorter OS as compared with the lower allele ratio group (P = 0.035).

Conclusion

Our results indicate that the impact of DNMT3A R882 mutations on AML prognosis was determined by the mutant-allele ratio and higher allele ratio could predict a worse prognosis, which might improve AML risk stratification. In addition, DNMT3A R882 mutations were associated with an inferior response to induction therapy with aclarubicin in Chinese AML patients.

SUBMITTER: Yuan XQ 

PROVIDER: S-EPMC6621981 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Influence of DNMT3A R882 mutations on AML prognosis determined by the allele ratio in Chinese patients.

Yuan Xiao-Qing XQ   Chen Peng P   Du Yin-Xiao YX   Zhu Ke-Wei KW   Zhang Dao-Yu DY   Yan Han H   Liu Han H   Liu Yan-Ling YL   Cao Shan S   Zhou Gan G   Zeng Hui H   Chen Shu-Ping SP   Zhao Xie-Lan XL   Yang Jing J   Zeng Wen-Jing WJ   Chen Xiao-Ping XP  

Journal of translational medicine 20190710 1


<h4>Background</h4>The influence of DNMT3A R882 mutations on adult acute myeloid leukemia (AML) prognosis is still controversial presently. The influence of R882 allele ratio on drug response and prognosis of AML is unknown yet. Besides, it is obscure whether anthracyclines are involved in chemoresistance resulted from R882 mutations.<h4>Methods</h4>DNMT3A R882 mutations in 870 adult AML patients receiving standard induction therapy were detected by pyrosequencing. Associations of the mutants wi  ...[more]

Similar Datasets

| S-EPMC4863771 | biostudies-literature
| S-EPMC6821681 | biostudies-literature
| S-EPMC3204995 | biostudies-literature
| S-EPMC8918526 | biostudies-literature
2023-12-31 | GSE226062 | GEO
| S-EPMC6868496 | biostudies-literature
| S-EPMC11006857 | biostudies-literature
| S-EPMC5063708 | biostudies-literature
| PRJNA938470 | ENA