Impact of AKI on Urinary Protein Excretion: Analysis of Two Prospective Cohorts.

ABSTRACT:

Background

Prior studies of adverse renal consequences of AKI have almost exclusively focused on eGFR changes. Less is known about potential effects of AKI on proteinuria, although proteinuria is perhaps the strongest risk factor for future loss of renal function.

Methods

We studied enrollees from the Assessment, Serial Evaluation, and Subsequent Sequelae of AKI (ASSESS-AKI) study and the subset of the Chronic Renal Insufficiency Cohort (CRIC) study enrollees recruited from Kaiser Permanente Northern California. Both prospective cohort studies included annual ascertainment of urine protein-to-creatinine ratio, eGFR, BP, and medication use. For hospitalized participants, we used inpatient serum creatinine measurements obtained as part of clinical care to define an episode of

SUBMITTER: Hsu CY 

PROVIDER: S-EPMC6622423 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature