Ontology highlight
ABSTRACT:
SUBMITTER: Marcar L
PROVIDER: S-EPMC6624074 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Marcar Lynnette L Bardhan Kankana K Gheorghiu Liliana L Dinkelborg Patrick P Pfäffle Heike H Liu Qi Q Wang Meng M Piotrowska Zofia Z Sequist Lecia V LV Borgmann Kerstin K Settleman Jeffrey E JE Engelman Jeffrey A JA Hata Aaron N AN Willers Henning H
Cell reports 20190601 12
Lung cancers with oncogenic mutations in the epidermal growth factor receptor (EGFR) invariably acquire resistance to tyrosine kinase inhibitor (TKI) treatment. Vulnerabilities of EGFR TKI-resistant cancer cells that could be therapeutically exploited are incompletely understood. Here, we describe a poly (ADP-ribose) polymerase 1 (PARP-1) inhibitor-sensitive phenotype that is conferred by TKI treatment in vitro and in vivo and appears independent of any particular TKI resistance mechanism. We fi ...[more]