Disruptions of the olfactory and default mode networks in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC6625464 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Disruptions of the olfactory and default mode networks in Alzheimer's disease.
Lu Jiaming J Yang Qing X QX Zhang Han H Eslinger Paul J PJ Zhang Xin X Wu Sichu S Zhang Bing B Zhu Bin B Karunanayaka Prasanna R PR
Brain and behavior 20190604 7
<h4>Introduction</h4>Olfactory deficits are prevalent in early Alzheimer's disease (AD) and are predictive of progressive memory loss and dementia. However, direct neural evidence to relate AD neurodegeneration to deficits in olfaction and memory is limited.<h4>Methods</h4>We combined the University of Pennsylvania Smell Identification Test (UPSIT) with olfactory functional magnetic resonance imaging (fMRI) to investigate links between neurodegeneration, the olfactory network (ON) and the defaul ...[more]
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