Ontology highlight
ABSTRACT:
SUBMITTER: Schober AF
PROVIDER: S-EPMC6625508 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cell reports 20190601 11
Enzyme function and evolution are influenced by the larger context of a metabolic pathway. Deleterious mutations or perturbations in one enzyme can often be compensated by mutations to others. We used comparative genomics and experiments to examine evolutionary interactions with the essential metabolic enzyme dihydrofolate reductase (DHFR). Analyses of synteny and co-occurrence across bacterial species indicate that DHFR is coupled to thymidylate synthase (TYMS) but relatively independent from t ...[more]