Unknown

Dataset Information

0

Air Pollution Alters Caenorhabditis elegans Development and Lifespan: Responses to Traffic-Related Nanoparticulate Matter.


ABSTRACT: Air pollution is a heterogeneous environmental toxicant that impacts humans throughout their life. We introduce Caenorhabditis elegans as a valuable air pollution model with its short lifespan, medium-throughput capabilities, and highly conserved biological pathways that impact healthspan. We exposed developmental and adult life stages of C. elegans to airborne nano-sized particulate matter (nPM) produced by traffic emissions and measured biological and molecular endpoints that changed in response. Acute nPM did not cause lethality in C. elegans, but short-term exposure during larval stage 1 caused delayed development. Gene expression responses to nPM exposure overlapped with responses of mouse and cell culture models of nPM exposure in previous studies. We showed further that the skn-1/Nrf2 antioxidant response has a role in the development and hormetic effects of nPM. This study introduces the worm as a new resource and complementary model for mouse and cultured cell systems to study air pollution toxicity across the lifespan.

SUBMITTER: Haghani A 

PROVIDER: S-EPMC6625599 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Air Pollution Alters Caenorhabditis elegans Development and Lifespan: Responses to Traffic-Related Nanoparticulate Matter.

Haghani Amin A   Dalton Hans M HM   Safi Nikoo N   Shirmohammadi Farimah F   Sioutas Constantinos C   Morgan Todd E TE   Finch Caleb E CE   Curran Sean P SP  

The journals of gerontology. Series A, Biological sciences and medical sciences 20190701 8


Air pollution is a heterogeneous environmental toxicant that impacts humans throughout their life. We introduce Caenorhabditis elegans as a valuable air pollution model with its short lifespan, medium-throughput capabilities, and highly conserved biological pathways that impact healthspan. We exposed developmental and adult life stages of C. elegans to airborne nano-sized particulate matter (nPM) produced by traffic emissions and measured biological and molecular endpoints that changed in respon  ...[more]

Similar Datasets

| S-EPMC7714337 | biostudies-literature
| S-EPMC4019010 | biostudies-literature
| S-EPMC8568481 | biostudies-literature
| S-EPMC3766279 | biostudies-literature
| S-EPMC3865717 | biostudies-literature
| S-EPMC6269216 | biostudies-literature
| S-EPMC4350321 | biostudies-literature
| S-EPMC4080540 | biostudies-literature
| S-EPMC9687064 | biostudies-literature
| S-EPMC6400491 | biostudies-literature