Ontology highlight
ABSTRACT:
SUBMITTER: Santos-Bezerra DP
PROVIDER: S-EPMC6626951 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Santos-Bezerra Daniele Pereira DP Admoni Sharon Nina SN Mori Rosana Cristina RC Pelaes Tatiana Souza TS Perez Ricardo Vesoni RV Machado Cleide Guimarães CG Monteiro Maria Beatriz MB Parisi Maria Candida MC Pavin Elizabeth Joao EJ Queiroz Marcia Silva MS Passarelli Marisa M Machado Ubiratan Fabres UF Correa-Giannella Maria Lucia ML
Journal of diabetes investigation 20190201 4
<h4>Aims/introduction</h4>Epigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization. We tested the hypothesis that genetic variants in an epigenetic gene could predispose to diabetes complications.<h4>Material and methods</h4>We assessed the frequency of five single-nucleotide polymorphisms in the gene encoding deoxyribonucleic acid methytransferase 1 (DNMT1; rs8112895, rs7254567, rs110857 ...[more]