Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC6626988 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Yu Meng M Bouley Bailey S BS Xie Da D Que Emily L EL
Dalton transactions (Cambridge, England : 2003) 20190601 25
We reported a set of water-soluble transition metal complexes that can serve as both 19F and PARACEST magnetic resonance imaging agents. The high number of equivalent fluorine atoms and the paramagnetic effect of metals offer these complexes high 19F sensitivity as demonstrated by in vitro19F MRI experiments. The complexes contain carboxamide groups appended onto a cyclen macrocycle, which provide 1H CEST peaks well differentiated from bulk water. The Co(ii) agent displays two CEST peaks that ca ...[more]