Ontology highlight
ABSTRACT:
SUBMITTER: Dasgupta S
PROVIDER: S-EPMC6627375 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Dasgupta Sayani S Fishman Michael A MA Castro Leandro M LM Tashima Alexandre K AK Ferro Emer S ES Fricker Lloyd D LD
Biomolecules 20190528 6
Peptides produced by the proteasome have been proposed to function as signaling molecules that regulate a number of biological processes. In the current study, we used quantitative peptidomics to test whether conditions that affect protein stability, synthesis, or turnover cause changes in the levels of peptides in Human Embryonic Kidney 293T (HEK293T) cells. Mild heat shock (42 °C for 1 h) or treatment with the deubiquitinase inhibitor b-AP15 led to higher levels of ubiquitinated proteins but d ...[more]